Tom McCullough expects Sauber to fight for points in Singapore but concedes the circuit is very different to Monza, where they brought in their biggest haul.
Last time out in Italy, Nico Hulkenberg qualified third on the grid and brought his C32 home in fifth place.
That earned the German and his team ten points towards their position in the Championship.
However, whether the team can produce a similar showing this weekend at Formula One's only night race remains to be seen as the nature of the street circuit is opposite to that of Monza's high-speed flowing layout.
"Singapore requires a totally different set-up philosophy compared to Monza," said McCullough. "The circuit efficiency sees a return to our maximum downforce level similar to Monaco.
"The track is dominated by tight, low-speed corners and this is the area that the mechanical and aero set-up is optimised around.
"Like Monza, the track is pretty bumpy in some areas, so placing an importance on ride quality. The stop-start nature of the circuit gives the brakes a hard time as there are not many opportunities per lap for them to cool down."
Sauber's Head of Track Engineering added that it is important for Hulkenberg and team-mate Esteban Gutierrez to put in a good showing during Saturday's qualifying while the team needs to factor in a Safety Car for Sunday's race.
"It is imperative to qualify strongly on Saturday evening, as overtaking on this track is difficult. The race tends to cross the two-hour mark and there is a high chance of a safety car at any time, which means this will keep the strategy engineers' attention throughout the whole race.
"The ambient conditions make it tough for the drivers and crew throughout the weekend. As in previous years, Pirelli has selected the supersoft compound as the option tyre, but the prime will be the medium compound, unlike last year when it was the soft compound.
"We will bring a further update package to Singapore that should help us to continue fighting for Championship points."