Being one of three races where Mercedes failed to win a race in 2015, Mercedes technical director Paddy Lowe is motivated to get the job done this time around.
Petronas, who is a sponsor of Mercedes, is also the country's national oil and gas company, which is another reason Lowe is looking forward to Sepang.
"We're all very much looking forward to Malaysia," Lowe explained.
"With Kuala Lumpur being the home of Petronas, we very much see this as one of our home Grand Prix.
"In 2015 we didn't manage to secure the win, which was hugely disappointing to us, so we have all the more motivation to come back and get it right this time around."
On the Sepang International Circuit, Lowe went onto explain that it is one of the more difficult tracks on the Formula 1 calendar due to the high demands.
"Focusing on the technical aspects of the circuit, it's a very challenging weekend,” he continued.
“The heat and humidity make life tough for drivers, team and cars alike, while the track action can often be affected by rain, which tends to be very heavy and arrive very suddenly.
"As such, we've seen some very eventful races in Malaysia over the years. The nominated tyre compounds for this event are the hard, medium and soft, with the unusual scenario of the hard as the obligatory race compound – meaning that, if the race remains dry, every driver must use that tyre.
"The characteristic of the circuit itself is more 'normal' than that of Monza or Singapore, which were more focused on more specific areas of car performance.
"Sepang places an even emphasis on power, aero efficiency and mechanical grip, so we're looking forward to seeing how we fare and aiming to put in a strong performance for the Malaysian fans."